An amyloid disease database for transthyretin mutants
| Analysis Tool | Result |
|---|---|
| iMutant 3.0 | Destabilizing |
| STRUM | Destabilizing |
| iStable | Stabilizing |
| Provean | Neutral |
| PredictSNP | Neutral |
| PhD-SNP | Neutral |
| PolyPhen-2 | Deleterious |
| SIFT | Neutral |
| FATHMM | Damaging |
| Analysis Tool | Result |
|---|---|
| mCSM | Destabilizing |
| SDM | Stabilizing |
| DUET | Stabilizing |
| DynaMut | Stabilizing |
| CUPSAT | Destabilizing |
| ENCoM | Destabilizing |
| FoldX (Protein Stability) | Enhances |
| Analysis Tool | Result |
|---|---|
| TANGO (Aggregation Tendency) | Increases |
| WALTZ (Amyloid Propensity) | No effect |
| LIMBO (Chaperone Binding Tendency) | No effect |